MOTS-C: Mitochondrial Peptide Research
Understanding This Mitochondrial-Derived Peptide and Its Role in Metabolic Studies
Short answer: MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA. It is studied for its role in AMPK activation and cellular energy regulation.
Last updated: 20 October 2026
Einleitung
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide that has attracted significant attention in metabolic and aging research. Unlike most peptides studied in laboratories, MOTS-c is encoded in the mitochondrial genome rather than nuclear DNA — making it a unique subject of scientific investigation.
Was ist MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded by the mitochondrial 12S rRNA gene. It was discovered in 2015 and is considered to play a role in metabolic regulation and cellular energy balance.
Key properties:
- 16 amino acids
- Mitochondrially-encoded
- Studied for metabolic regulation
- Considered to influence AMPK pathway
- Unique origin (mitochondrial DNA)
How MOTS-c Works
MOTS-c is posited to function through several potential mechanisms:
AMPK Activation
MOTS-c is considered to activate AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis. This pathway is studied for its potential role in:
- Glucose uptake
- Fatty acid oxidation
- Insulin sensitivity
Nuclear Gene Expression
Interestingly, MOTS-c appears to enter the cell nucleus and may influence gene expression related to metabolic processes — including the folate cycle and amino acid metabolism.
Forschungsanwendungen
- Metabolic research — Glucose and insulin metabolism studies
- Exercise science — Physical performance and adaptation
- Aging research — Cellular energy decline with age
- Mitochondrial biology — Mitochondrial-nuclear communication
Current Research Status
MOTS-c is a relatively newer compound in research, with most studies conducted in animal models. Researchers continue to investigate its mechanisms and potential applications.
Conclusion
MOTS-c represents a fascinating intersection of mitochondrial biology and metabolic research. Its unique origin as a mitochondrially-encoded peptide makes it a novel target for scientists studying cellular energy, aging, and metabolic regulation.
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Häufig gestellte Fragen
Where is MOTS-c encoded?
In the mitochondrial genome, in the 12S rRNA gene – unlike most peptides, which are encoded in nuclear DNA.
When was MOTS-c discovered?
In 2015.
Which pathway is MOTS-c studied with?
AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis.
Related: MOTS-C 10mg · Lab reports (COA)